Small controlled human study
Spindle et al. (2024), Vaporized D-limonene selectively mitigates the acute anxiogenic effects of delta-9-THC — Drug and Alcohol Dependence 257:111267
Twenty healthy adults who intermittently used cannabis completed controlled vaporization sessions. Co-administered d-limonene reduced some subjective THC-related anxiety measures. The study does not establish treatment for an anxiety disorder or predict the effects of a commercial strain.











